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KMID : 0380020100250040330
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Korean Journal of Biotechnology and Bioengineering
2010 Volume.25 No. 4 p.330 ~ p.336
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Melanin Biosynthesis Inhibitory Effect of New Compound ( Jeju-Erythrane) Isolated from Bark of Lindera erythrocarpa Makino
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Kang Min-Chul
Ko Ryeo-Kyeoung
Kim Su-Gyeong
Choi Ho-Min
Jin Yeong-Jun
Han Jong-Heon
Kim Bong-Seok
Lee Nam-Ho
Kim Gi-Ok
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Abstract
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In this study, a new compound, 1-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)-1-methoxy-3-phenylpropane; (Jeju-Erythrane) was isolated and identified from the bark of Lindera erythrocarpa Makino. Also, we investigated the effects of Jeju-Erythrane on alpha melanocyte-stimulating hormone (MSH)-induced melanogenesis in mouse B16F10 melanoma cells. The new compound dose dependently inhibited the tyrosinase activity and melanin synthesis in B16F10 cells. The new compound showed inhibitory effect on the Tyrosinase and TRP-1 gene transcription but not on the TRP-2 gene. These results suggest that the new compound of L. erythrocarpa could be used as a functional biomaterial in developing skin whitening agent.
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KEYWORD
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Lindera erythrocarpa Makino, Jeju-Erythrane, tyrosinase activity, melanin content
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